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Cytarabine

CAS No.:147-94-4

Description

Cytarabine:
Alias:cytosine-1-beta-D-arabinofuranoside, cytosine arabinoside , 4-amino-1-[(2R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one , 4-AMino-1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)pyriMidin-2(1H)-one
Purity:98% --102%
Product Standard:CP , USP ,EP 

 

General Specification:
【CAS No.】147-94-4
【molecular formula】C9H13N3O5
【molecular weight】243.22
【EINECS number 】205-705-9
【Product Name】cytosine-1-beta-D-arabinofuranoside
【Package 】25kg/drum、200kg/Drum、 1000kg/IBC’
【Storage 】Sealed storage at room temperature and away from light, validity two years

 

Technical Data:

Item

Standard

Appearance(+25°C)

Prisms from EtOH (aq) crystalline

Purity %

98% --102%

Odour

Odorless or almost odorless

solubility

almost transparency

Main ingredients

Cytarabine

pH value(25℃)

 4.3 

Residue on ignition

≤0.1%

Relative Density

1.3686
Melting point 214 °C

 

Pharmacologic Action:

   Cytarabine is a pyrimidine antimetabolite that mainly acts on cell S proliferation phase, and interferes with cell proliferation by inhibiting cellular DNA synthesis. After entering the body, cytarabine is phosphorylated by kinase and converted into cytarabine triphosphate and cytarabine diphosphate, the former of which strongly inhibits the synthesis of DNA polymerase, while the latter inhibits the conversion of cytarabine diphosphate into deoxycytidine diphosphate, thereby inhibiting cellular DNA polymerization and synthesis.

 

Product Usage:

   Cytarabine is mainly used in acute leukemia: it is most effective in acute granulocytic leukemia, and is also effective in acute monocytic leukemia and acute lymphoblastic leukemia. It is usually used in combination with other drugs. It is effective for malignant lymphoma, lung cancer, gastrointestinal tract cancer, head and neck cancer, and also for viral keratitis and epidemic conjunctivitis, etc.

 

 

Application Cases: 
 Injections

 

 

 

 

 

Application Method:

   Cytarabine is a pyrimidine antimetabolite that acts as long as it acts in the proliferative phase of cells S. It is mainly used in acute myelogenous leukemia, acute lymphoid leukemia and lymphoma, and it is a central drug in the treatment of these diseases in the induction of chemotherapy.
Cytarabine has antiviral effects and is used to treat various herpes virus infections. However, due to its poor antiviral selectivity and its ability to cause myelosuppression and other serious adverse effects, cytarabine is still mainly used in malignant hematologic diseases. In addition, cytarabine has also been used in neurological studies to control the proliferation of glial cells.

 

Storage:
Store in a cool, ventilated warehouse. Avoid light . The temperature of the warehouse should not exceed 37℃. It should be stored separately from oxidants and edible chemicals. Do not mix storage to keep the container sealed. Keep away from fire and heat. Lightning protection equipment must be installed in the warehouse.

 

Authoritative test report:
Through the third party authority testing , quality can be guaranteed 

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Key Word:

cytosine-1-beta-D-arabinofuranoside

Cytarabine

CAS No.:147-94-4


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辽ICP备2021002629号  web:300.cn jinzhou.300.cn SEO