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Methotrexate (MTX)

CAS:7413-34-5

Description

Methotrexate
Purity:98.0%-102.0%
Product Standard :United States Pharmacopeia(USP) 
Alias:Methotrexate disodium salt ,Trexan),Amethopterin,MTX,Emthexate,FarmachemiceB.V,Farmothrex(Farmos)。
DL-Amethopterin hydrate
4-Amino-10-methylfolic acid
DL-4-Amino-N10-methylpteroylglutamic acid
Methotrexate
Methylaminopterin

 

General Specification:
【CAS No.】7413-34-5  /59-05-2
【molecular formula】C20H20N8Na2O5
【molecular Weight】498.4
【EINECS No.】231-022-0
【Package】25kg/drum
【Storage】Keep away from moisture, sealed store in a cool place.
 

Technical Specification:

Item

Specification

Appearance

This product should be a yellow crystalline powder

Identification

Infrared spectrum, UV should conform to the regulations

Solubility

Almost insoluble in water, ethanol (96%) and methylene chloride. A dilute solution soluble in dilute inorganic acids, bases, hydroxides, and carbonates

Moisture

≤18.0%

Residue on ignition

≤0.1%

Heavy Metal

≤20ppm

Impurities

Impurity C≤0.5%

Impurity B≤0.3%

Impurity E≤0.3%

Impurity I≤0.2%

Impurity H≤0.2%

other impurities≤0.1%

total impurities≤1.0%

enantiomeric purity≤3%

Solvent Residue

acetone≤5000ppm

ethyl alcohol≤5000ppm

Purity

98.0%-102.0%

 

Product Usage:
Methotrexate, an organic compound, is mainly used as an antifolate antitumor drug. It can inhibit the synthesis of tumor cells and inhibit the growth and reproduction of tumor cells by inhibiting dihydrofolate reductase.

 

Pharmacologic action:
Tetrahydrofolate is an important coenzyme for the synthesis of purine nucleotides and pyrimidine deoxynucleotides in vivo. As a folate reductase inhibitor, this product mainly inhibits dihydrofolate reductase and prevents the reduction of dihydrofolate into tetrahydrofolate with physiological activity, thus blocking the transfer of carbon groups during the biosynthesis of purine nucleotides and pyrimidine nucleotides. Which leads to the inhibition of DNA biosynthesis. In addition, this product also has an inhibitory effect on thymus nucleotide synthase, but the inhibitory effect on RNA and protein synthesis is weak. This product mainly acts on the S phase of the cell cycle, which is a cell cycle specific drug. It also has a delaying effect on G1/S phase cells, but has a weak effect on G1 phase cells. 

 

Package& storage:
25kg/drum
【Storage】Keep away from moisture, sealed store in a cool place.

 

Key Word:

Methotrexate

CAS 59-05-2


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辽ICP备2021002629号  web:300.cn jinzhou.300.cn SEO