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2,2'-Anhydro-1-beta-D-arabinofuranosylcytosine hydrochloride

CAS NO. 10212-25-6

Description

2,2'-Anhydro-1-beta-D-arabinofuranosylcytosine hydrochloride
Alias:Cyclocytidine hydrochloride、(2R,3R,3aS,6E,9aR)-2-(hydroxymethyl)-6-imino-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5][1,3]oxazolo[3,2-a]pyrimidin-3-ol; (6E)-2-(hydroxymethyl)-6-imino-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5][1,3]oxazolo[3,2-a]pyrimidin-3-ol; 2-(hydroxymethyl)-6-imino-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5][1,3]oxazolo[3,2-a]pyrimidin-3-ol
Purity:99%
Product Standard:CP , USP ,EP 

 

General Specification:
【CAS No.】10212-25-6
【molecular formula】C9H11N3O4· HCl
【molecular weight】261.66
【EINECS number 】233-515-6
【Product Name】Cyclocytidine hydrochloride、2,2'-dihydro-1-beta-D-arabinofuranosylcytosine hydrochloride
【Package 】25kg/drum、200kg/Drum、 1000kg/IBC’
【Storage 】Sealed storage at room temperature and away from light, validity two years

 

Technical Data:

Item

Standard

Appearance(+25°C)

White powder

Purity %

99

Odour

Odorless or almost odorless

solubility

Soluble in water, slightly soluble in methanol and ethanol, almost insoluble in ether, benzene and chloroform

Main ingredients

Cyclocytidine hydrochloride

Boiling point

442℃ at 760 mmHg

Residue on ignition

≤0.1%

Melting point 269-270 °C (dec.)(lit.)
Sensitivity Easily absorbing moisture

 

Pharmacologic Action:Cyclocytidine hydrochloride is a condensed compound of cytidine, which is characterized as stable to cytidine deaminase and stable to other metabolic enzymes. It is converted intracellularly to cytidine triphosphate, which interferes with DNA polymerase and DNA synthesis. It is a cell cycle-specific drug that acts mainly in the S phase and has a delaying effect on the G1/S and S/G2 boundaries. It has a therapeutic effect in malignant lymphoma.

 

Product Usage:
Antiseptic has a very strong broad spectrum antibacterial, bactericidal effect, have the ability to kill gram-positive bacteria and Gram-negative bacteria . Widely used for skin disinfection, surgical disinfection, instrument disinfection irrigation wound, bladder irrigation burns, burns, can also be used for oral anti-inflammatory, truscutis and abdominal cavity and intestinal mucosa disinfection in surgery, also used for daily tableware, vegetables and fruits, drinking water disinfection. Chlorhexidine gluconate aqueous solution is often prepared clinically for various purposes of disinfection.

 

Application Cases:

Intramuscular or oral, same dose as sedation. Intrathecal injection for meningeal leukemia

 

 

 

 

 

Application Method:

1. Sedative drip: Adults 200-600mg (4-12mg per kg body weight) each time, dissolved in 5% glucose solution or isotonic saline injection 500ml, once a day, for 5-10 days for a course of treatment. 2. Intramuscular injection and oral administration: the dose is the same as intravenous injection. 3. Intrathecal injection: for meningeal leukemia, adults 50-100mg dissolved in 2ml of isotonic saline injection, once daily or every other day. 4. Eye drops: 1 drop every 1 to 2 hours, or use eye ointment, apply 4 to 6 times daily.

 

Storage:
Store in a cool, ventilated warehouse. Avoid light . The temperature of the warehouse should not exceed 37℃. It should be stored separately from oxidants and edible chemicals. Do not mix storage to keep the container sealed. Keep away from fire and heat. Lightning protection equipment must be installed in the warehouse.

 

Authoritative test report:
Through the third party authority testing , quality can be guaranteed 

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Key Word:

2

2'-Anhydro-1-beta-D-arabinofuranosylcytosine hydrochloride

CAS NO. 10212-25-6

Cyclocytidine hydrochloride

cytidine deaminase


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辽ICP备2021002629号  web:300.cn jinzhou.300.cn SEO